New article on prevention of rehospitalization of patients with bipolar disorder

28.02.2018 – Our new article on Real-World effectiveness of pharmacologic treatments for the prevention of rehospitalization in a Finnish nationwide cohort of patients with bipolar disorder has been published in JAMA Network.

We aimed to investigate what pharmacologic treatments are most likely to prevent rehospitalization with patients suffering from bipolar disorder.

A little is known about the overall health outcomes associated with specific treatments, such as mood stabilizers and antipsyhotics, their comparative long-term effectiveness or their routes of administration in prevention of rehospitalizations.

This cohort study examined the risk of psychiatric, cardiovascular, and all-cause hospitalization from 1987 to 2012, among all 18 018 patients in Finland who had been hospitalized for bipolar disorder using prospectively gathered nationwide databases for hospitalization and dispensed medications. The primary analysis was within-individual analysis, in which each individual was used as his or her own control to eliminate selection bias. The study adjusted for the effect of concomitant psychotropic medications, duration of illness, and the temporal orders of exposure and nonexposure periods.

Lithium was the most effective mood stabilizer, and long-acting injections the most effective antipsychotics, in preventing hospitalization due to mental or physical illness.

Lähteenvuo M, Tanskanen A, Taipale H. Real-World effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients With Bipolar Disorder. Published online in JAMA Network, February 28, 2018. – Read abstract